姓名：常明明
所在系室：生物工程
研究方向： 功能肽的研究与开发，控缓释药物制剂研究。硕士生导师，民盟昌平区工委委员，民盟市委第十三届农业农村委员会委员。主持或参与国家自然科学基金1项，北京市自然科学基金1项及其他各级各类科研基金项目5项，发表科研论文10篇，授权发明专利5项。主持完成3项校级教学改革项目，参加1项校级教学改革项目，发表教改论文7篇。
邮箱：changmingming@bua.edu.cn
教育经历：
2002.9-2013.10大连理工大学工学博士
2006.9-2009.7 大连理工大学 理学硕士
2002.9-2006.7大连理工大学 工学学士
工作经历：
2013年至今 北京农学院生物与资源环境学院生物工程系主任，硕士生导师
2016-2018年 清华大学 生物医学工程系 访问学者
代表作：
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1. Xinwei Zhang, Ziping Wang, Yu Bai, Yulun Hu, Qing Chen*, Yueping Liu*, Mingming Chang*.Therapeutic Effect of a Near-Infrared Responsive MTX-Mn3O4@PDA Nano-Delivery System on Rheumatoid Arthritis. Advanced Therapeutics (just accepted) doi.org/10.1002/adtp.202400345
2. Tingting Guo, Xu Kang, Sifan Ren, Xianjin Ouyang, Mingming Chang*. Construction of a Nano-Controlled Release Methotrexate Delivery System for the Treatment of Rheumatoid Arthritis by Local Percutaneous Administration, Nanomaterials, 2021.11（11）2812.
3. Mingming Chang, Qing Wang,* et al. Effect of cationic cyclopeptides on transdermal and transmembrane delivery of insulin. Molecular Pharmaceutics, 2013,10 (3): 951-957.
4. Mingming Chang, Qing Wang* et al. A Potential Mechanism of a Cationic- Cyclopeptide for Enhancing Insulin Delivery across Caco-2 Cell Monolayers. Biological and Pharmaceutical Bulletin, 2013, 36(10): 1602-1607。
5. 康旭，郭婷婷，欧阳先进，任思凡，郭蓓，常明明*.甲氨蝶呤控释给药系统的构建及治疗效果[J].北京农学院学报, 2022, 37(04): 91-95.
6. 欧阳先进,郭婷婷,康旭，刘悦萍，常明明*。长寿花叶片组织培养与离体快繁研究[J].北京农学院学报,2022,37(03):20-24..
7. 欧阳先进,康旭,郭婷婷，刘悦萍，常明明*.介孔二氧化硅纳米粒在药物输送领域中的应用[J].中国医药导报,2023,20(03):59-62.
8. 常明明，李晓晖，孙玉明，汪晴*。具有经皮促渗功能的阳离子环肽构效关系研究。2013年中国药物制剂大会/论文汇编,544-546。
9. 常明明，孙玉明，汪晴*。不同中药压敏胶贴片中有效成分的体外释放研究。 中成药，2010，32(1): 43-47。
授权国家发明专利：
1. 常明明,郭婷婷,邵祺等. 具有抗菌活性的阿诺普林改造肽及其合成方法和应用[P]. CN113583090B, 2023-06-23.
2. 常明明,郭婷婷,康旭. 甲氨蝶呤经皮给药局部控释制剂及其制备方法和应用[P]. CN109985248B, 2022-03-15.
3. 常明明,安祥顺,谢阳村等. 一种具有环状结构的抗菌肽及其制备方法和应用[P]. CN105566452A, 2016-05-11.
编著出版物：
1. 《生物工程综合实验指导》，副主编，2020，普通高等教育农业农村部“十三五”规划教材，普通高等农林院校“十三五”规划教材，中国农业出版社。
2. 《制药工艺学》，参编，2023，全国中医药行业高等教育“十四五”规划教材，中国中医药出版社。
3. 《制药技术人员从业指南》参编，2024，普通高等教育本科化工与制药类教材，中国医药科技出版社。
主讲课程：
本科生课程：《化工原理》、《酶工程》、《生物制剂》
研究生课程：《制药工艺与技术》
获奖荣誉：
1. 北京市普通高校优秀本科生毕业设计（论文）
2. 北京农学院本科生教学成果奖二等奖（第一完成人）
3. 作为指导教师指导学生获得挑战杯、生物学竞赛和化工原理竞赛等各种学科竞赛省部级奖项25项。
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CURRICULUM VITAE
Personal Information
Name: |
Mingming Chang |
Date of Birth: |
December 18, 1982 |
Phone No. |
01080795433 |
E-mail: |
changmingming@bua.edu.cn |
Education Background
2013.11-Now Teacher, College of Bioscience and Resources Environment, Beijing University of Agriculture，China.
2016.3-2018.7 Exchange, Department of biomedical engineering, Tsinghua University, China.
2010.1-2013.10 PhD, School of Pharmaceutical Science and Technology, Dalian University of Technology, China.
2006.7-2009.12 Master, School of Chemical Engineering, Dalian University of Technology, China.
2002.9-2006.7 Bachelor, School of Chemical Engineering, Dalian University of Technology, China.
Research Interests:
1. Research and development of functional peptides.
2. Research on controlled and sustained release drug delivery system.
Main Publications
1. Xinwei Zhang, Ziping Wang, Yu Bai, Yulun Hu, Qing Chen*, Yueping Liu*, Mingming Chang*.Therapeutic Effect of a Near-Infrared Responsive MTX-Mn3O4@PDA Nano-Delivery System on Rheumatoid Arthritis. Advanced Therapeutics (Just accepted) doi.org/10.1002/adtp. 202400345.
2. Tingting Guo, Xu Kang, Sifan Ren, Xianjin Ouyang, Mingming Chang*. Construction of a Nano-Controlled Release Methotrexate Delivery System for the Treatment of Rheumatoid Arthritis by Local Percutaneous Administration, Nanomaterials, 2021.11（11）2812.
3. Mingming Chang, Xiaohui Li, Yuming Sun, Fang Cheng, Yueqing Li, Weijie Zhao, Qing Wang*.A potential Mechanism of a Cationic Cyclopeptide for Enhancing Insulin Delivery across Caco-2 Cell Monolayers. Biological Pharma ceutical bulletin. 2013, 36 (10): 1602-1607.
4. Mingming Chang, Xiaohui Li, Yuming Sun, Fang Cheng, Qing Wang*, Weijie Zhao, Xiaohuan Xie, Weijie Zhao, Xin Tian*. Effect of Cationic Cyclopeptides on Transdermal and Transmembrane Delivery of Insulin. Molecular Pharmaceutics. 2013, 10:951-957.
5. Xiaohui Li, Mingming Chang*, Qing Wang*, Yuming Sun, Yang Liu. Influence of cationic cyclopeptide on microstructure and permeability of Caco-2 cell membrane. Acta Pharmaceutica Sinica 2014, 49 (7): 1062 -1068.
6. Xu Kang, Tingting Guo, Xianjin Ouyang, Sifan Ren, Bei Guo, Mingming Chang*.Construction and effect of methotrexate controlled release drug delivery system. Journal of Beijing University of Agriculture. 2022,37(4):91-95.
Chinese Patent
1. Mingming Chang, Tingting Guo, Xu Kang. Preparation Method and Application of Methotrexate Local Controlled Release Formulation for Percutaneous Delivery. (ZL201910417042.8)
2. Mingming Chang , Xiang shun An, Yangcun Xie, Feiyan Xue, Xufan Lian, Xu Wen, Can Liu, Xiaomeng Zhao. Preparation method and application of a cyclic antibacterial peptide. (ZL 201610045474.7)
3. Xiaohui Li, , Qing Wang, Mingming Chang. A group of peptides with promoting transdermal and transmembrane permeability and their applications. (ZL2013100526582)
Professional Skills
A. Drug delivery system
(1) Synthesis nano-particals ( SiO2, Fe3O4, Au) .
(2) Construction and evaluation of nano-controlled release drug delivery system.
B. Peptide field.
(1) Standerd solid phase peptide synthesis technology.
(2) Structure and activity relationship of peptide.
(3) Desigh, synthesis and evaluate of peptide.
C. Protein field
Protein modification, separation and purification.
